User:Peyton Jenkins/Sandbox 1
From Proteopedia
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== Relevance and Disease == | == Relevance and Disease == | ||
Lung cancer is the leading cause of cancer related death worldwide. In the United States alone, over 120,000 deaths were caused by lung cancer in 2024<ref>https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2024/2024-cancer-facts-and-figures-acs.pdf</ref>. Non small cell lung cancer make up approximately 84% of all lung cancer cases, and of these lung adenocarcinoma accounts for about 65%<ref>10.1001/jamaoncol.2021.4932</ref>. In lung adenocarcinoma, ''STK11'' is the third most commonly mutated gene, behind only ''KRAS'' and ''p53''<ref>10.1091/mbc.E15-08-0569.</ref>. | Lung cancer is the leading cause of cancer related death worldwide. In the United States alone, over 120,000 deaths were caused by lung cancer in 2024<ref>https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2024/2024-cancer-facts-and-figures-acs.pdf</ref>. Non small cell lung cancer make up approximately 84% of all lung cancer cases, and of these lung adenocarcinoma accounts for about 65%<ref>10.1001/jamaoncol.2021.4932</ref>. In lung adenocarcinoma, ''STK11'' is the third most commonly mutated gene, behind only ''KRAS'' and ''p53''<ref>10.1091/mbc.E15-08-0569.</ref>. | ||
| - | STK11 is a master kinase, signalling upstream of AMPK family kinases, p53, FAK, to regulate processes like anoikis, adhesion, growth, metabolism, and survival<ref>10.1038/sj.emboj.7600110</ref><sup>, </sup><ref>10.1074/jbc.M112.444620</ref>. STK11 exists in a | + | STK11 is a master kinase, signalling upstream of AMPK family kinases, p53, FAK, to regulate processes like anoikis, adhesion, growth, metabolism, and survival<ref>10.1038/sj.emboj.7600110</ref><sup>, </sup><ref>10.1074/jbc.M112.444620</ref>. STK11 exists in a heterotrimeric complex with the pseudokinase STRADα, and the scaffolding protein Mo25. This complex is essential for both proper kinase activity and proper localization. <ref>10.1038/sj.emboj.7600110</ref><sup>, </sup> <ref>10.1093/emboj/cdg490</ref> |
== Structural Highlights == | == Structural Highlights == | ||
Revision as of 22:46, 26 April 2025
8VSU: Heterotrimeric Complex of STK11, Mo25, and STRADa
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