User:Peyton Jenkins/Sandbox 1
From Proteopedia
(Difference between revisions)
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| - | ==2WTK: Hetertrimeric Complex of STK11, | + | ==2WTK: Hetertrimeric Complex of STK11, MO25, and STRADα== |
<StructureSection load='2WTK' size='340' side='right' caption='Heterotrimeric Complex of STK11, MO25, STRADα' scene=''> | <StructureSection load='2WTK' size='340' side='right' caption='Heterotrimeric Complex of STK11, MO25, STRADα' scene=''> | ||
== Relevance and Disease == | == Relevance and Disease == | ||
Lung cancer is the leading cause of cancer related death worldwide. In the United States alone, over 120,000 deaths were caused by lung cancer in 2024<ref>https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2024/2024-cancer-facts-and-figures-acs.pdf</ref>. Non small cell lung cancer make up approximately 84% of all lung cancer cases, and of these lung adenocarcinoma accounts for about 65%<ref>10.1001/jamaoncol.2021.4932</ref>. In lung adenocarcinoma, ''STK11'' is the third most commonly mutated gene, behind only ''KRAS'' and ''p53''<ref>10.1091/mbc.E15-08-0569.</ref>. | Lung cancer is the leading cause of cancer related death worldwide. In the United States alone, over 120,000 deaths were caused by lung cancer in 2024<ref>https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2024/2024-cancer-facts-and-figures-acs.pdf</ref>. Non small cell lung cancer make up approximately 84% of all lung cancer cases, and of these lung adenocarcinoma accounts for about 65%<ref>10.1001/jamaoncol.2021.4932</ref>. In lung adenocarcinoma, ''STK11'' is the third most commonly mutated gene, behind only ''KRAS'' and ''p53''<ref>10.1091/mbc.E15-08-0569.</ref>. | ||
| - | STK11 is a master kinase, signalling upstream of AMPK family kinases, p53, FAK, to regulate processes like anoikis, adhesion, growth, metabolism, and survival<ref>10.1038/sj.emboj.7600110</ref><sup>, </sup><ref>10.1074/jbc.M112.444620</ref>. STK11 exists in a heterotrimeric complex with the pseudokinase STRADα, and the scaffolding protein | + | STK11 is a master kinase, signalling upstream of AMPK family kinases, p53, FAK, to regulate processes like anoikis, adhesion, growth, metabolism, and survival<ref>10.1038/sj.emboj.7600110</ref><sup>, </sup><ref>10.1074/jbc.M112.444620</ref>. STK11 exists in a heterotrimeric complex with the pseudokinase STRADα, and the scaffolding protein MO25. This complex is essential for both proper kinase activity and proper localization. <ref>10.1038/sj.emboj.7600110</ref><sup>, </sup> <ref>10.1093/emboj/cdg490</ref> |
== Structural Highlights == | == Structural Highlights == | ||
| - | ''' | + | '''Breaking down the proteins:''' STK11 can be broken down into 3 domains. An N-terminal domain (1-42), kinase domain (43-347), and a C-terminal domain (348-433). STRADα is composed of two domains, an N-terminal domain (1-58) and a pseudo kinase domain (59-431) |
| + | '''Holding the complex together:''' The C-terminus of MO25 interacts with a WEF motif (429-431) on the C-terminus of STRADα | ||
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== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 23:49, 28 April 2025
2WTK: Hetertrimeric Complex of STK11, MO25, and STRADα
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