User:Jacob A. Ray/Sandbox 1
From Proteopedia
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CD44 is a highly glycosylated multifunctional cell surface receptor that is involved in cell-cell interaction and maintenance of the extracellular matrix.<ref>DOI 10.3389/fcell.2017.00018</ref> The primary ligand for CD44 is hyaluronan (HA), but it has also been found to interact with other molecules including osteopontin (OPN), collagens, and fibronectin. <ref>DOI 10.1136/mp.52.4.189</ref> CD44 is a single chain protein containing four distinct regions: the N-terminal HA binding <scene name='10/1079558/Link_domain/2'>Link domain</scene><ref>DOI 10.1016/S1097-2765(04)00080-2</ref>, a flexible variable domain, a transmembrane domain, and an intracellular signaling domain.<ref>DOI 10.3389/fcell.2017.00018</ref> | CD44 is a highly glycosylated multifunctional cell surface receptor that is involved in cell-cell interaction and maintenance of the extracellular matrix.<ref>DOI 10.3389/fcell.2017.00018</ref> The primary ligand for CD44 is hyaluronan (HA), but it has also been found to interact with other molecules including osteopontin (OPN), collagens, and fibronectin. <ref>DOI 10.1136/mp.52.4.189</ref> CD44 is a single chain protein containing four distinct regions: the N-terminal HA binding <scene name='10/1079558/Link_domain/2'>Link domain</scene><ref>DOI 10.1016/S1097-2765(04)00080-2</ref>, a flexible variable domain, a transmembrane domain, and an intracellular signaling domain.<ref>DOI 10.3389/fcell.2017.00018</ref> | ||
| - | == Sequence Conservation == | ||
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== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|right|200px]] | [[Image:Consurf_key_small.gif|right|200px]] | ||
Revision as of 01:48, 30 April 2025
CD44
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References
- ↑ Senbanjo LT, Chellaiah MA. CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells. Front Cell Dev Biol. 2017 Mar 7;5:18. PMID:28326306 doi:10.3389/fcell.2017.00018
- ↑ Goodison S, Urquidi V, Tarin D. CD44 cell adhesion molecules. Mol Pathol. 1999 Aug;52(4):189-96. PMID:10694938 doi:10.1136/mp.52.4.189
- ↑ doi: https://dx.doi.org/10.1016/S1097-2765(04)00080-2
- ↑ Senbanjo LT, Chellaiah MA. CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells. Front Cell Dev Biol. 2017 Mar 7;5:18. PMID:28326306 doi:10.3389/fcell.2017.00018
