DNA repair protein
From Proteopedia
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== Function == | == Function == | ||
| - | '''DNA repair protein Rad4''' is a yeast protein involved in DNA damage recognition in nucleotide excision repair<ref>PMID:15916602</ref>. Rad4 is an ortholog of the XPC protein. Rad4 opens up damaged DNA by inserting β-hairpin into the duplex and flipping out two damage-containing nucleotide pairs<ref>PMID:27035942</ref>. | + | '''DNA repair proteins''' correct DNA damage caused by mutations or toxins<ref>PMID:7773744</ref>. |
| + | *'''DNA repair protein Rad4''' is a yeast protein involved in DNA damage recognition in nucleotide excision repair<ref>PMID:15916602</ref>. Rad4 is an ortholog of the XPC protein. Rad4 opens up damaged DNA by inserting β-hairpin into the duplex and flipping out two damage-containing nucleotide pairs<ref>PMID:27035942</ref>. | ||
== Disease == | == Disease == | ||
| - | Mutations in | + | Mutations in '''DNA repair protein Rad4''' can cause the xeroderma pigmentosum skin cancer predisposition syndrome<ref>PMID:17882165</ref>. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 06:52, 30 April 2025
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Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
