8za6

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m (Protected "8za6" [edit=sysop:move=sysop])
Current revision (10:24, 30 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8za6 is ON HOLD
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==Cryo-EM structure of the gdTCR-CD3 complex==
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<StructureSection load='8za6' size='340' side='right'caption='[[8za6]], [[Resolution|resolution]] 3.43&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8za6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZA6 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.43&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8za6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8za6 OCA], [https://pdbe.org/8za6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8za6 RCSB], [https://www.ebi.ac.uk/pdbsum/8za6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8za6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:[https://omim.org/entry/610163 610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.<ref>PMID:16672702</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bai Y]]
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[[Category: Huang Z]]
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[[Category: Zhu Y]]

Current revision

Cryo-EM structure of the gdTCR-CD3 complex

PDB ID 8za6

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