9jvw

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Current revision (10:37, 30 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9jvw is ON HOLD until Paper Publication
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==Overall structure of human EAAT2 bound with inhibitor (WAY-213613)==
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<StructureSection load='9jvw' size='340' side='right'caption='[[9jvw]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
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Authors: Xia, L.Y., Zhang, Y.Y., Shi, Y., Huang, J., Zhou, Q.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9jvw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JVW FirstGlance]. <br>
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Description: Overall structure of human EAAT2 bound with inhibitor (WAY-213613)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.41&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=GJ0:(2~{S})-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic+acid'>GJ0</scene></td></tr>
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[[Category: Huang, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jvw OCA], [https://pdbe.org/9jvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jvw RCSB], [https://www.ebi.ac.uk/pdbsum/9jvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jvw ProSAT]</span></td></tr>
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[[Category: Zhang, Y.Y]]
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</table>
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[[Category: Xia, L.Y]]
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== Disease ==
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[[Category: Zhou, Q]]
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[https://www.uniprot.org/uniprot/EAA2_HUMAN EAA2_HUMAN] Non-specific early-onset epileptic encephalopathy. The disease is caused by variants affecting the gene represented in this entry.
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[[Category: Shi, Y]]
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== Function ==
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[https://www.uniprot.org/uniprot/EAA2_HUMAN EAA2_HUMAN] Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).[UniProtKB:P43006]<ref>PMID:15265858</ref> <ref>PMID:26690923</ref> <ref>PMID:7521911</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang J]]
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[[Category: Shi Y]]
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[[Category: Xia LY]]
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[[Category: Zhang YY]]
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[[Category: Zhou Q]]

Current revision

Overall structure of human EAAT2 bound with inhibitor (WAY-213613)

PDB ID 9jvw

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OCA

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