JMS/Sandbox/msn2
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Joseph M. Steinberger (Talk | contribs)
(New page: {{DISPLAYTITLE:MSN2 (P33748) — Stress-responsive transcription factor}} __NOTOC__ == Interactive 3-D Model == <applet load='AF-P33748-F1-model_v4' size='400' align='right' caption='Alpha...)
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Revision as of 14:24, 4 May 2025
Interactive 3-D Model
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- Full-length model (restore the starting view)
- Zinc finger DNA-binding domain
- Regulated nuclear-localization signal (NLS)
- PKA phosphorylation cluster
- C2H2 zinc-binding motif
- Intrinsically disordered regions (IDRs)
- Confidence coloring (pLDDT)
Quick Guide
- **C-terminal zinc finger (645-704)** binds STRE/G-quadruplex DNA.
- **Regulated NLS (618-633)** is masked by **PKA phosphorylation** (S582, S620, S625, S633) to control stress-dependent nuclear import.
- Most of the N-terminal 600 aa are **intrinsically disordered**, housing the NES and trans-activation motifs.
- Per-residue **pLDDT** values (confidence coloring scene) highlight the single well-folded domain vs. the flexible IDRs.
AlphaFold PDB header and full sequence: :contentReference[oaicite:2]{index=2}:contentReference[oaicite:3]{index=3}