JMS/Sandbox/msn2
From Proteopedia
(Difference between revisions)
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=== Zinc Fingers === | === Zinc Fingers === | ||
Msn2 binds DNA via two C2H2 zinc finger domains located in the C-terminal region (residues 647-665 and 676-698).[4] These domains recognize the Stress Response Element (STRE) in the promoters of target genes.[1, 45] The AlphaFold model predicts these domains with high confidence (blue regions in the default view). Click the link to highlight these domains and the coordinating Zinc ions. | Msn2 binds DNA via two C2H2 zinc finger domains located in the C-terminal region (residues 647-665 and 676-698).[4] These domains recognize the Stress Response Element (STRE) in the promoters of target genes.[1, 45] The AlphaFold model predicts these domains with high confidence (blue regions in the default view). Click the link to highlight these domains and the coordinating Zinc ions. | ||
+ | |||
+ | (<jmol><jmolLink> | ||
+ | <script> | ||
+ | select 647-665, 676-698; color magenta; backbone 0.7; wireframe 0.15; | ||
+ | select zn; spacefill 1.2; color cpk; | ||
+ | selectionHalos ON; delay 1.5; selectionHalos OFF; | ||
+ | center selected; zoom 150; | ||
+ | </script> | ||
+ | <text>Highlight Zinc Fingers (DNA Binding: 647-665, 676-698)</text> | ||
+ | </jmolLink></jmol>) | ||
(<jmol><jmolLink> | (<jmol><jmolLink> |
Revision as of 13:42, 5 May 2025
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Zinc Fingers
Msn2 binds DNA via two C2H2 zinc finger domains located in the C-terminal region (residues 647-665 and 676-698).[4] These domains recognize the Stress Response Element (STRE) in the promoters of target genes.[1, 45] The AlphaFold model predicts these domains with high confidence (blue regions in the default view). Click the link to highlight these domains and the coordinating Zinc ions.
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The precise interaction with DNA likely involves specific residues within these fingers making contact with the STRE sequence.
Click below to view the structure colored by pLDDT: