JMS/Sandbox/msn2

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</script>
</script>
<text>Highlight Predicted Disordered Regions (84-246, 418-437, 592-634)</text>
<text>Highlight Predicted Disordered Regions (84-246, 418-437, 592-634)</text>
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(<jmol><jmolLink>
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<script>
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select 288, 582, 620, 625, 633; color red; spacefill 100%; wireframe off; # Show PKA site sidechains
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selectionHalos ON; delay 1.5; selectionHalos OFF; # Blink selection
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center selected; zoom 150;
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</script>
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<text>Highlight Key PKA Phosphorylation Sites (S288, S582, S620, S625, S633)</text>
</jmolLink></jmol>)
</jmolLink></jmol>)

Revision as of 13:49, 5 May 2025

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Zinc Fingers

Msn2 binds DNA via two C2H2 zinc finger domains located in the C-terminal region (residues 647-665 and 676-698).[4] These domains recognize the Stress Response Element (STRE) in the promoters of target genes.[1, 45] The AlphaFold model predicts these domains with high confidence (blue regions in the default view). Click the link to highlight these domains and the coordinating Zinc ions.

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() Explanation: Selects the 9aaTAD motif (residues 261-269 ). Colors it yellow and displays it as a trace (smoothed backbone representation) for clarity within potentially disordered regions. The selection blinks, and the view centers/zooms.   4.6. Highlight Key PKA Phosphorylation Sites (S288, S582, S620, S625, S633) Focuses specifically on the sidechains of the key PKA sites regulating Msn2 localization. Code snippet

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Joseph M. Steinberger

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