JMS/Sandbox/msn2
From Proteopedia
| Line 20: | Line 20: | ||
color atoms property bfactor range 0 100; | color atoms property bfactor range 0 100; | ||
color atoms property_bfactor >= 90 "#084594"; | color atoms property_bfactor >= 90 "#084594"; | ||
| - | color atoms property_bfactor < 90 "#084594"; | ||
</script> | </script> | ||
<text>Reset View (Color by pLDDT Confidence)</text> | <text>Reset View (Color by pLDDT Confidence)</text> | ||
Revision as of 14:24, 5 May 2025
- Msn2 (P33748): Interactive Structure of a Yeast Stress-Responsive Transcription Factor
|
- Introduction
Msn2 (UniProt P33748) is a key transcription factor in *Saccharomyces cerevisiae* (baker's yeast) that orchestrates the general stress response (GSR).[1, 2] Along with its paralog Msn4, it binds to Stress Response Elements (STREs) in the promoters of numerous genes involved in protecting the cell against diverse environmental challenges like heat shock, osmotic stress, and nutrient limitation.[3, 2] Msn2's activity is primarily regulated by its dynamic localization between the cytoplasm and the nucleus, a process controlled by phosphorylation, notably by Protein Kinase A (PKA).[2, 4]
This page utilizes the AlphaFold structural prediction for Msn2 [5, 6] and interactive Jmol scripting to explore key functional domains and regulatory sites.
- Interactive Exploration
Use the links below to highlight specific features on the 3D model to the right. The default view colors the structure by AlphaFold's prediction confidence (pLDDT score), ranging from very low confidence (red) through low (yellow) and confident (green) to very high confidence (blue).[5]
()
()
