Dynein 3D structures

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Current revision (07:59, 6 May 2025) (edit) (undo)
 
Line 8: Line 8:
**[[2e8j]], [[2b95]], [[1z09]] - hDYNC 2A – human – NMR<BR />
**[[2e8j]], [[2b95]], [[1z09]] - hDYNC 2A – human – NMR<BR />
**[[2hz5]] - hDYNC 2A<BR />
**[[2hz5]] - hDYNC 2A<BR />
 +
**[[8rgi]] - hDYNC 1+2B axonemal<BR />
**[[1y4o]] - mDYNC 2A – mouse<BR />
**[[1y4o]] - mDYNC 2A – mouse<BR />
**[[1re6]] - mDYNC 2 – NMR<BR />
**[[1re6]] - mDYNC 2 – NMR<BR />
Line 18: Line 19:
**[[5wi4]] - yDYNC TcTex1 - yeast<br />
**[[5wi4]] - yDYNC TcTex1 - yeast<br />
**[[5wof]] – DYNC 1 – ''Plasmodium falciparum''<BR />
**[[5wof]] – DYNC 1 – ''Plasmodium falciparum''<BR />
-
**[[1xdx]], [[1m9l]], [[1ds9]] - CrDYNC TcTex1 – ''Chlamydomonas reinhardtii'' – NMR<BR />
+
**[[1xdx]], [[1m9l]], [[1ds9]] - CrDYNC TcTex1 axonemal – ''Chlamydomonas reinhardtii'' – NMR<BR />
-
**[[5yxm]] - CrDYNC <br />
+
**[[5yxm]] - CrDYNC axonemal<br />
**[[3rjs]] - DYNC – ''Toxoplasma gondii''<br />
**[[3rjs]] - DYNC – ''Toxoplasma gondii''<br />
Line 31: Line 32:
**[[4qh8]], [[4qh7]] - DmDYNC + anastral spindle 2<br />
**[[4qh8]], [[4qh7]] - DmDYNC + anastral spindle 2<br />
**[[3dvp]], [[3brl]], [[3e2b]], [[5e0l]], [[5e0m]], [[7k3j]], [[7k3k]], [[7k3l]] - DmDYNC + peptide<BR />
**[[3dvp]], [[3brl]], [[3e2b]], [[5e0l]], [[5e0m]], [[7k3j]], [[7k3k]], [[7k3l]] - DmDYNC + peptide<BR />
 +
**[[7y8w]] - DYNC + suppressor of APH-1<BR />
**[[4ds1]] - yDYNC + nucleoporin Nup129 peptide <br />
**[[4ds1]] - yDYNC + nucleoporin Nup129 peptide <br />
**[[4ht6]] – yDYNC + PAC11 peptide<br />
**[[4ht6]] – yDYNC + PAC11 peptide<br />
-
**[[6l4p]] – CrDYNC + DYNC heavy chain 1614-1757<br />
+
**[[6l4p]] – CrDYNC axonemal + DYNC heavy chain 1614-1757<br />
**[[7jts]] – CrDYNC + radial spoke protein + microtubules + calmodulin – Cryo EM<br />
**[[7jts]] – CrDYNC + radial spoke protein + microtubules + calmodulin – Cryo EM<br />
**[[7jtk]] – CrDYNC + radial spoke protein + cytochrome b5 heme-binding domain containing protein – Cryo EM<br />
**[[7jtk]] – CrDYNC + radial spoke protein + cytochrome b5 heme-binding domain containing protein – Cryo EM<br />
Line 39: Line 41:
*Dynein intermediate chain
*Dynein intermediate chain
-
**[[3l7h]] – DmDYNC intermediate chain light chain roadblock <BR />
+
**[[3l7h]] – DmDYNC intermediate chain light chain roadblock axonemal<BR />
-
**[[3l9k]] - DmDYNC intermediate chain light chain roadblock + intermediate chain<BR />
+
**[[3l9k]] - DmDYNC intermediate chain light chain roadblock axonemal + intermediate chain<BR />
-
**[[3fm7]], [[3glw]], [[2pg1]], [[2p2t]] - DmDYNC intermediate chain + light chain<br />
+
**[[3fm7]], [[3glw]], [[2pg1]], [[2p2t]] - DmDYNC intermediate chain + light chain axonem<br />
**[[5hyc]] – rbfDYNC 2<br />
**[[5hyc]] – rbfDYNC 2<br />
**[[6pqt]] – CtDYNC N-terminal – ''Chaetomium thermophilum'' - NMR<br />
**[[6pqt]] – CtDYNC N-terminal – ''Chaetomium thermophilum'' - NMR<br />
Line 55: Line 57:
*Dynein heavy chain
*Dynein heavy chain
-
**[[5nug]], [[6f1v]] – hDYNC – Cryo EM<br />
+
**[[6f1v]] – hDYNC 1-1186 – Cryo EM<br />
-
**[[5owo]] – hDYNC <br />
+
**[[5owo]] – hDYNC N-terminal dimerization domain 1-201 cystoplasmic<br />
-
**[[8dyu]], [[8dyv]] – hDYNC + PAFAH – Cryo EM<br />
+
**[[8i3j]] – hDYNC axonemal<br />
-
**[[5ayh]] – mDYNC <br />
+
**[[3wuq]], [[5ayh]] – mDYNC stalk region 3207-3475<br />
-
**[[3err]] - mDYNC microtubule-binding domain/Ser-tRNA synthetase<br />
+
**[[3err]] - mDYNC stalk region/Ser-tRNA ligase<br />
-
**[[3wuq]] - mDYNC stalk domain<br />
+
**[[3j1t]] – mDYNC stalk region/Ser-tRNA ligase + tubulin α-1B chain<br />
-
**[[3j1t]] - mDYNC + tubulin α-1B chain<br />
+
**[[3j1u]] - mDYNC stalk region/Ser-tRNA ligase + tubulin α-1B+β-2B chains<br />
-
**[[3j1u]] - mDYNC + tubulin α-1B+β-2B chains<br />
+
**[[6rza]], [[6rzb]] - mDYNC microtubule-binding domain axonemal + tubulin α-1B+β-2B chains – Cryo EM<r />
-
**[[6rza]], [[6rzb]] - mDYNC microtubule-binding domain + tubulin α-1B+β-2B chains – Cryo EM<r />
+
**[[6kjn]] – yDYNC 3095-3232 - NMR<br />
**[[6kjn]] – yDYNC 3095-3232 - NMR<br />
**[[6kjo]] – yDYNC 3095-3232 (mutant) - NMR<br />
**[[6kjo]] – yDYNC 3095-3232 (mutant) - NMR<br />
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**[[4w8f]] – yDYNC/lysozyme (mutant) + AMPPNP<br />
**[[4w8f]] – yDYNC/lysozyme (mutant) + AMPPNP<br />
**[[5vh9]], [[5vlj]] – yDYNC 1448-3028,3298-4092 + LIS1 + ATP - CryoEM<br />
**[[5vh9]], [[5vlj]] – yDYNC 1448-3028,3298-4092 + LIS1 + ATP - CryoEM<br />
 +
**[[8dzz]], [[8e00]] – yDYNC 1448-4092 + LIS1 + ADP + ATP - CryoEM<br />
**[[6kio]], [[6kiq]] – yDYNC 3095-3224 + pTubulin α-1A+β chains – Cryo EM<br />
**[[6kio]], [[6kiq]] – yDYNC 3095-3224 + pTubulin α-1A+β chains – Cryo EM<br />
**[[3vkg]], [[3vkh]] - DYNC – ''Dictyostelium discoideum''<br />
**[[3vkg]], [[3vkh]] - DYNC – ''Dictyostelium discoideum''<br />
-
**[[2rr7]] – CrDYNC microtubule-binding domain<br />
+
**[[2rr7]] – CrDYNC microtubule-binding domain axonemal<br />
**[[3j6p]] - DYNC + tubulin α-1B chain – slime mold<br />
**[[3j6p]] - DYNC + tubulin α-1B chain – slime mold<br />
-
**[[6zyy]] – TtDYNC + shulin + ADP + ATP - ''Tetrahymena thermophila'' - Cryo EM<br />
+
**[[6zyy]] – TtDYNC axonemal + shulin + ADP + ATP - ''Tetrahymena thermophila'' - Cryo EM<br />
-
*Dynein motor domain
+
*Dynein heavy+intermediate chains
 +
**[[8pqw]], [[8pqy]], [[8pqz]] – hDYNC + dynactin + PAF-AH – Cryo EM<br />
 +
 +
*Dynein motor domain 1-4646
 +
 +
**[[8pqv]] – hDYNC (mutant) – Cryo EM<br />
**[[4rh7]] – hDYNC + ADP + ATP<br />
**[[4rh7]] – hDYNC + ADP + ATP<br />
-
**[[7z8f]], [[7z8g]], [[7z8h]], [[7z8i]], [[7z8j]], [[7z8k]], [[7z8l]] – hDYNC (mutant) + ADP + ATP + ANP – Cryo EM<br
+
**[[5nug]], [[9blz]], [[9bm0]], [[9bm1]], [[9bm2]], [[9bm3]], [[9bm4]], [[9bm5]], [[9bm6]], [[9bm7]], [[9bm8]], [[9bma]], [[9bmb]], [[9bmc]], [[9bmd]], [[9bmf]], [[9bmg]], [[9bmh]], [[9bmj]], [[9bmj]], [[9bml]], [[9bmm]], [[9bmn]], [[9bmo]], [[9bmp]], [[9bmr]], [[9bms]], [[9bmt]], [[9bmu]], [[9bmv]], [[9bmw]], [[9bmy]], [[9bmz]], [[9bn0]], [[9bn1]], [[9bn3]], [[9bn4]], [[9bn5]], [[9bn6]], [[9dh5]], [[9dh8]] – hDYNC+ ADP + ATP – Cryo EM<br />
 +
**[[9dha]] – hDYNC+ AMPPNP – Cryo EM<br />
 +
**[[9dh9]] – hDYNC + ADP + ATP + ANP – Cryo EM<br >
 +
**[[7z8f]], [[7z8g]], [[7z8h]], [[7z8i]], [[7z8j]], [[7z8k]], [[7z8l]] – hDYNC (mutant) + ADP + ATP + ANP – Cryo EM<br >
 +
**[[9dh6]], [[9dh7]] – hDYNC + AMPPNP – Cryo EM<br >
**[[6rla]] – hDYNC/alkylguanine-DNA alkyltransferase + ADP + ATP – Cryo EM<br />
**[[6rla]] – hDYNC/alkylguanine-DNA alkyltransferase + ADP + ATP – Cryo EM<br />
 +
**[[8fcy]], [[8fd6]] – hDYNC/Ser-tRNA ligase + ADP + ATP – Cryo EM<br />
 +
**[[8dyu]], [[8dyv]] – hDYNC 1320-4646 + PAF-AH + ADP + ATP – Cryo EM<br />
 +
**[[8fdt]], [[8fdu]] – hDYNC 1458-3277/Ser-tRNA ligase + PAF-AH + ADP + ATP – Cryo EM<br />
**[[3j68]], [[3j67]] – DYNC – sea urchin<br />
**[[3j68]], [[3j67]] – DYNC – sea urchin<br />
**[[4aki]], [[4akg]] – yDYNC + ATP<br />
**[[4aki]], [[4akg]] – yDYNC + ATP<br />
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*Dynein tail
*Dynein tail
-
**[[6f1y]] – hDYNC heavy+light+intermediate – CryoEM<br />
+
**[[6f1y]], [[8rgg]], [[8rgh]] – hDYNC heavy+light+intermediate – CryoEM<br />
 +
**[8pr1]], [[8pr2]], [[8pr3]], [[8pr5]] – hDYNC heavy+light+intermediate + JIP-3 – CryoEM<br />
**[[5nvs]] – hDYNC heavy+light+intermediate + LC8 + TcTex + ROBL – CryoEM<br />
**[[5nvs]] – hDYNC heavy+light+intermediate + LC8 + TcTex + ROBL – CryoEM<br />
**[[5nvu]] – hDYNC motor+heavy+light+intermediate + LC8 + TcTex + ROBL – CryoEM<br />
**[[5nvu]] – hDYNC motor+heavy+light+intermediate + LC8 + TcTex + ROBL – CryoEM<br />
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**[[6f1u]], [[6f1t]] – pDYNC heavy+light+intermediate + dynactin + BICDR1 - Cryo EM<br />
**[[6f1u]], [[6f1t]] – pDYNC heavy+light+intermediate + dynactin + BICDR1 - Cryo EM<br />
**[[6f38]] – pDYNC heavy+light+intermediate + dynactin + HOOK3 - Cryo EM<br />
**[[6f38]] – pDYNC heavy+light+intermediate + dynactin + HOOK3 - Cryo EM<br />
-
**[[6zyx]] – TtDYNC heavy+light+intermediate + shulin + GTP - Cryo EM<br />
+
**[[6zyx]] – TtDYNC axonemal heavy+light+intermediate + shulin + GTP - Cryo EM<br />
* Dynein arm core subcomplex
* Dynein arm core subcomplex
-
**[[7k58]], [[7k5b]], [[7kek]], [[7kzn]], [[7kzo]] – CrDYNC + DC1 + DC2 – CryoEM<br />
+
**[[7k58]], [[7k5b]], [[7kek]], [[7kzn]], [[7kzo]] – CrDYNC axonemal + DC1 + DC2 – CryoEM<br />
**[[7kzm]] – CrDYNC + DC1 + DC2 + DC3 + GDP + GTP – CryoEM<br />
**[[7kzm]] – CrDYNC + DC1 + DC2 + DC3 + GDP + GTP – CryoEM<br />
-
**[[6zyw]], [[7moq]] – TtDYNC + thioredoxin + shulin + ADP + ATP + GTP – CryoEM <br />
+
**[[8bwy]] – CrDYNC axonemal + ADP + ATP – CryoEM<br />
 +
**[[6zyw]], [[7moq]] – TtDYNC axonemal + thioredoxin + shulin + ADP + ATP + GTP – CryoEM <br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Dynein

Updated on 06-May-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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