9lfu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:09, 7 May 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9lfu is ON HOLD until Paper Publication
+
==Crystal structure of human RIP3 kinase domain complexed with LK01003==
-
 
+
<StructureSection load='9lfu' size='340' side='right'caption='[[9lfu]], [[Resolution|resolution]] 2.93&Aring;' scene=''>
-
Authors: Xie, H., Su, H.X., Li, M.J., Xu, Y.C.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9lfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LFU FirstGlance]. <br>
-
Description: Crystal structure of human RIP3 kinase domain complexed with LK01003
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.93&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D97:2-cyclopentyl-~{N}-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine'>A1D97</scene></td></tr>
-
[[Category: Li, M.J]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lfu OCA], [https://pdbe.org/9lfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lfu RCSB], [https://www.ebi.ac.uk/pdbsum/9lfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lfu ProSAT]</span></td></tr>
-
[[Category: Xu, Y.C]]
+
</table>
-
[[Category: Xie, H]]
+
== Function ==
-
[[Category: Su, H.X]]
+
[https://www.uniprot.org/uniprot/RIPK3_HUMAN RIPK3_HUMAN] Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.<ref>PMID:19498109</ref> <ref>PMID:19524512</ref> <ref>PMID:19524513</ref> <ref>PMID:22265413</ref> <ref>PMID:22265414</ref> <ref>PMID:22421439</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Li MJ]]
 +
[[Category: Su HX]]
 +
[[Category: Xie H]]
 +
[[Category: Xu YC]]

Current revision

Crystal structure of human RIP3 kinase domain complexed with LK01003

PDB ID 9lfu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9lfu"
Personal tools