9lfw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:09, 7 May 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9lfw is ON HOLD until Paper Publication
+
==Crystal structure of mouse RIP3 kinase domain(R69H) complexed with LK01003==
-
 
+
<StructureSection load='9lfw' size='340' side='right'caption='[[9lfw]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9lfw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LFW FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D97:2-cyclopentyl-~{N}-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine'>A1D97</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lfw OCA], [https://pdbe.org/9lfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lfw RCSB], [https://www.ebi.ac.uk/pdbsum/9lfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lfw ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Mus musculus]]
 +
[[Category: Li MJ]]
 +
[[Category: Su HX]]
 +
[[Category: Xie H]]
 +
[[Category: Xu YC]]

Current revision

Crystal structure of mouse RIP3 kinase domain(R69H) complexed with LK01003

PDB ID 9lfw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9lfw"
Personal tools