1vrq

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[[Image:1vrq.gif|left|200px]]
[[Image:1vrq.gif|left|200px]]
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{{Structure
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|PDB= 1vrq |SIZE=350|CAPTION= <scene name='initialview01'>1vrq</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1vrq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DMG:N,N-DIMETHYLGLYCINE'>DMG</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=FON:FOLINIC+ACID'>FON</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Sarcosine_oxidase Sarcosine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.3.1 1.5.3.1] </span>
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|GENE=
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{{STRUCTURE_1vrq| PDB=1vrq | SCENE= }}
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|RELATEDENTRY=[[1x31|1X31]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vrq OCA], [http://www.ebi.ac.uk/pdbsum/1vrq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vrq RCSB]</span>
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'''Crystal Structure of Heterotetrameric Sarcosine Oxidase from Corynebacterium sp. U-96 in complex with Folinic Acid'''
'''Crystal Structure of Heterotetrameric Sarcosine Oxidase from Corynebacterium sp. U-96 in complex with Folinic Acid'''
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[[Category: Moriguchi, T.]]
[[Category: Moriguchi, T.]]
[[Category: Suzuki, H.]]
[[Category: Suzuki, H.]]
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[[Category: flavoenzyme]]
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[[Category: Flavoenzyme]]
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[[Category: heterotetrameric sarcosine oxidase]]
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[[Category: Heterotetrameric sarcosine oxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:50:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:27:45 2008''
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Revision as of 09:50, 3 May 2008

Image:1vrq.gif

Template:STRUCTURE 1vrq

Crystal Structure of Heterotetrameric Sarcosine Oxidase from Corynebacterium sp. U-96 in complex with Folinic Acid


Overview

Sarcosine oxidase from Corynebacterium sp. U-96 is a heterotetrameric enzyme. Here we report the crystal structures of the enzyme in complex with dimethylglycine and folinic acid. The alpha subunit is composed of two domains, contains NAD(+), and binds folinic acid. The beta subunit contains dimethylglycine, FAD, and FMN, and these flavins are approximately 10A apart. The gamma subunit is in contact with two domains of alpha subunit and has possibly a folate-binding structure. The delta subunit contains a single atom of zinc and has a Cys(3)His zinc finger structure. Based on the structures determined and on the previous works, the structure-function relationship on the heterotetrameric sarcosine oxidase is discussed.

About this Structure

1VRQ is a Protein complex structure of sequences from Corynebacterium sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96., Ida K, Moriguchi T, Suzuki H, Biochem Biophys Res Commun. 2005 Jul 29;333(2):359-66. PMID:15946648 Page seeded by OCA on Sat May 3 12:50:38 2008

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