1vsc
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1vsc.gif|left|200px]] | [[Image:1vsc.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1vsc", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | | | + | {{STRUCTURE_1vsc| PDB=1vsc | SCENE= }} |
| - | | | + | |
| - | + | ||
| - | }} | + | |
'''VCAM-1''' | '''VCAM-1''' | ||
| Line 28: | Line 25: | ||
[[Category: Stehle, T.]] | [[Category: Stehle, T.]] | ||
[[Category: Wang, J.]] | [[Category: Wang, J.]] | ||
| - | [[Category: | + | [[Category: Cell adhesion protein]] |
| - | [[Category: | + | [[Category: Glycoprotein]] |
| - | [[Category: | + | [[Category: Immunoglobulin fold]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:51:52 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:51, 3 May 2008
VCAM-1
Overview
Vascular cell adhesion molecule 1 (VCAM-1) represents a structurally and functionally distinct class of immunoglobulin superfamily molecules that bind leukocyte integrins and are involved in inflammatory and immune functions. X-ray crystallography defines the three-dimensional structure of the N-terminal two-domain fragment that participates in ligand binding. Residues in domain 1 important for ligand binding reside in the C-D loop, which projects markedly from one face of the molecule near the contact between domains 1 and 2. A cyclic peptide that mimics this loop inhibits binding of alpha 4 beta 1 integrin-bearing cells to VCAM-1. These data demonstrate how crystallographic structural information can be used to design a small molecule inhibitor of biological function.
About this Structure
1VSC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction., Wang JH, Pepinsky RB, Stehle T, Liu JH, Karpusas M, Browning B, Osborn L, Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5714-8. PMID:7539925 Page seeded by OCA on Sat May 3 12:51:52 2008
