9fq3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==HEV ORF2 protein in complex with Fabs Es1.114 and Es5.127== | |
| - | + | <StructureSection load='9fq3' size='340' side='right'caption='[[9fq3]], [[Resolution|resolution]] 3.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9fq3]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepeviridae Hepeviridae] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FQ3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fq3 OCA], [https://pdbe.org/9fq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fq3 RCSB], [https://www.ebi.ac.uk/pdbsum/9fq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fq3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAPSD_HEVUS CAPSD_HEVUS] Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.<ref>PMID:29669922</ref> Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity). The nuclear form probably modulates host gene expression (By similarity).[UniProtKB:P29326][UniProtKB:P33426][UniProtKB:Q81871] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hepeviridae]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Baquero E]] | ||
| + | [[Category: Molinos L]] | ||
| + | [[Category: Mouquet H]] | ||
Current revision
HEV ORF2 protein in complex with Fabs Es1.114 and Es5.127
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