9n36

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Current revision (05:35, 28 May 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9n36 is ON HOLD until Paper Publication
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==CryoEM structure Of Respiratory Syncytial Virus Polymerase with novel non-nucleoside inhibitor compound 22==
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<StructureSection load='9n36' size='340' side='right'caption='[[9n36]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9n36]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_orthopneumovirus Human orthopneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9N36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9N36 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BVR:5-(5-bromanyl-1-methyl-2-oxidanylidene-spiro[indole-3,4-piperidine]-1-yl)-3-chloranyl-pyridine-2-carbonitrile'>A1BVR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9n36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9n36 OCA], [https://pdbe.org/9n36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9n36 RCSB], [https://www.ebi.ac.uk/pdbsum/9n36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9n36 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/L_HRSVA L_HRSVA] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).<ref>PMID:8445369</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human orthopneumovirus]]
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[[Category: Large Structures]]
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[[Category: Kalin JH]]
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[[Category: Sharma S]]
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[[Category: Tran MT]]
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[[Category: Yin Y]]
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[[Category: Yu X]]

Current revision

CryoEM structure Of Respiratory Syncytial Virus Polymerase with novel non-nucleoside inhibitor compound 22

PDB ID 9n36

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OCA

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