7lqi
From Proteopedia
(Difference between revisions)
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<StructureSection load='7lqi' size='340' side='right'caption='[[7lqi]], [[Resolution|resolution]] 3.50Å' scene=''> | <StructureSection load='7lqi' size='340' side='right'caption='[[7lqi]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LQI FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CR:N-ACETYL-L-PHENYLALANINE'>5CR</scene>, <scene name='pdbligand=GMA:4-AMIDO-4-CARBAMOYL-BUTYRIC+ACID'>GMA</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CR:N-ACETYL-L-PHENYLALANINE'>5CR</scene>, <scene name='pdbligand=GMA:4-AMIDO-4-CARBAMOYL-BUTYRIC+ACID'>GMA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqi OCA], [https://pdbe.org/7lqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqi RCSB], [https://www.ebi.ac.uk/pdbsum/7lqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqi ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqi OCA], [https://pdbe.org/7lqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqi RCSB], [https://www.ebi.ac.uk/pdbsum/7lqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The self-assembly of designed peptides into filaments and other higher-order structures has been the focus of intense interest because of the potential for creating new biomaterials and biomedical devices. These peptide assemblies have also been used as models for understanding biological processes, such as the pathological formation of amyloid. We investigate the assembly of an octapeptide sequence, Ac-FKFEFKFE-NH2, motivated by prior studies that demonstrated that this amphipathic beta strand peptide self-assembled into fibrils and biocompatible hydrogels. Using high-resolution cryoelectron microscopy (cryo-EM), we are able to determine the atomic structure for two different coexisting forms of the fibrils, containing four and five beta sandwich protofilaments, respectively. Surprisingly, the inner walls in both forms are parallel beta sheets, while the outer walls are antiparallel beta sheets. Our results demonstrate the chaotic nature of peptide self-assembly and illustrate the importance of cryo-EM structural analysis to understand the complex phase behavior of these materials at near-atomic resolution. | ||
| - | |||
| - | Deterministic chaos in the self-assembly of beta sheet nanotubes from an amphipathic oligopeptide.,Wang F, Gnewou O, Wang S, Osinski T, Zuo X, Egelman EH, Conticello VP Matter. 2021 Oct 6;4(10):3217-3231. doi: 10.1016/j.matt.2021.06.037. Epub 2021, Jul 27. PMID:34632372<ref>PMID:34632372</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 7lqi" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Synthetic construct]] | ||
[[Category: Conticello VP]] | [[Category: Conticello VP]] | ||
[[Category: Egelman EH]] | [[Category: Egelman EH]] | ||
[[Category: Gnewou OM]] | [[Category: Gnewou OM]] | ||
[[Category: Wang F]] | [[Category: Wang F]] | ||
Current revision
Cryo-EM of KFE8 thicker nanotube
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