1zaf

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(New page: 200px<br /> <applet load="1zaf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zaf, resolution 2.20&Aring;" /> '''Crystal structure o...)
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Revision as of 18:25, 12 November 2007

Image:1zaf.gif

1zaf, resolution 2.20Å

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Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one

Overview

The syntheses of a series of 2-arylindene-1-ones as potent ligands of, ERbeta and ERalpha are described. Several compounds exhibited high potency, and moderate selectivity for the ERbeta receptor. X-ray and modeling, studies were used to understand ligand binding orientation and observed, affinity.

About this Structure

1ZAF is a Protein complex structure of sequences from Homo sapiens with 789 as ligand. Active as Histone acetyltransferase, with EC number 2.3.1.48 Full crystallographic information is available from OCA.

Reference

Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones., McDevitt RE, Malamas MS, Manas ES, Unwalla RJ, Xu ZB, Miller CP, Harris HA, Bioorg Med Chem Lett. 2005 Jun 15;15(12):3137-42. PMID:15876535

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