1zag
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(New page: 200px<br /> <applet load="1zag" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zag, resolution 2.80Å" /> '''HUMAN ZINC-ALPHA-2-...)
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Revision as of 18:25, 12 November 2007
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HUMAN ZINC-ALPHA-2-GLYCOPROTEIN
Overview
Zn-alpha2-glycoprotein (ZAG) is a soluble protein that is present in serum, and other body fluids. ZAG stimulates lipid degradation in adipocytes and, causes the extensive fat losses associated with some advanced cancers. The, 2.8 angstrom crystal structure of ZAG resembles a class I major, histocompatibility complex (MHC) heavy chain, but ZAG does not bind the, class I light chain beta2-microglobulin. The ZAG structure includes a, large groove analogous to class I MHC peptide binding grooves. Instead of, a peptide, the ZAG groove contains a nonpeptidic compound that may be, implicated in lipid catabolism under normal or pathological conditions.
About this Structure
1ZAG is a Single protein structure of sequence from Homo sapiens with NAG and NDG as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules., Sanchez LM, Chirino AJ, Bjorkman P, Science. 1999 Mar 19;283(5409):1914-9. PMID:10206894
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