This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1vzv
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1vzv.gif|left|200px]] | [[Image:1vzv.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1vzv", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | | | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | + | --> | |
| - | + | {{STRUCTURE_1vzv| PDB=1vzv | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE''' | '''STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE''' | ||
| Line 24: | Line 21: | ||
Crystal structure of varicella-zoster virus protease., Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS, Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9096314 9096314] | Crystal structure of varicella-zoster virus protease., Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS, Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9096314 9096314] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Varicella-zoster virus (isolate 40a2)]] | ||
[[Category: Abdel-Meguid, S S.]] | [[Category: Abdel-Meguid, S S.]] | ||
[[Category: Culp, J S.]] | [[Category: Culp, J S.]] | ||
| Line 32: | Line 28: | ||
[[Category: Richardson, S B.]] | [[Category: Richardson, S B.]] | ||
[[Category: Smith, W W.]] | [[Category: Smith, W W.]] | ||
| - | [[Category: | + | [[Category: Coat protein]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Serine protease]] |
| - | [[Category: | + | [[Category: Varicella-zoster virus]] |
| - | [[Category: | + | [[Category: Viral protease]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:58:03 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:58, 3 May 2008
STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE
Overview
Varicella-zoster virus (VZV), an alpha-herpes virus, is the causative agent of chickenpox, shingles, and postherpetic neuralgia. The three-dimensional crystal structure of the serine protease from VZV has been determined at 3.0-A resolution. The VZV protease is essential for the life cycle of the virus and is a potential target for therapeutic intervention. The structure reveals an overall fold that is similar to that recently reported for the serine protease from cytomegalovirus (CMV), a herpes virus of the beta subfamily. The VZV protease structure provides further evidence to support the finding that herpes virus proteases have a fold and active site distinct from other serine proteases. The VZV protease catalytic triad consists of a serine and two histidines. The distal histidine is proposed to properly orient the proximal histidine. The identification of an alpha-helical segment in the VZV protease that was mostly disordered in the CMV protease provides a better definition of the postulated active site cavity and reveals an elastase-like S' region. Structural differences between the VZV and CMV proteases also suggest potential differences in their oligomerization states.
About this Structure
1VZV is a Single protein structure of sequence from Varicella-zoster virus (isolate 40a2). Full crystallographic information is available from OCA.
Reference
Crystal structure of varicella-zoster virus protease., Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS, Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. PMID:9096314 Page seeded by OCA on Sat May 3 12:58:03 2008
