9gim

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Current revision (08:27, 4 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9gim is ON HOLD until Paper Publication
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==Full-lenght Nedd4-2 E3 ubiquitin ligase in presence of Ca2+==
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<StructureSection load='9gim' size='340' side='right'caption='[[9gim]], [[Resolution|resolution]] 4.11&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9gim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GIM FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.11&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gim OCA], [https://pdbe.org/9gim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gim RCSB], [https://www.ebi.ac.uk/pdbsum/9gim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gim ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NED4L_HUMAN NED4L_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.<ref>PMID:12911626</ref> <ref>PMID:15217910</ref> <ref>PMID:15489223</ref> <ref>PMID:15040001</ref> <ref>PMID:15496141</ref> <ref>PMID:15576372</ref> <ref>PMID:19144635</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Janosev M]]
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[[Category: Kosek D]]
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[[Category: Obsil T]]
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[[Category: Obsilova V]]

Current revision

Full-lenght Nedd4-2 E3 ubiquitin ligase in presence of Ca2+

PDB ID 9gim

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