9hap

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Current revision (08:28, 4 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9hap is ON HOLD until Paper Publication
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==Cryo-EM structure of inactive human arginine-vasopressin (AVP) V2 receptor (V2R) with tolvaptan==
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<StructureSection load='9hap' size='340' side='right'caption='[[9hap]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9hap]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HAP FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IT8:~{N}-[4-[[(5~{R})-7-chloranyl-5-oxidanyl-2,3,4,5-tetrahydro-1-benzazepin-1-yl]carbonyl]-3-methyl-phenyl]-2-methyl-benzamide'>A1IT8</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hap OCA], [https://pdbe.org/9hap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hap RCSB], [https://www.ebi.ac.uk/pdbsum/9hap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hap ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/V2R_HUMAN V2R_HUMAN] Nephrogenic syndrome of inappropriate antidiuresis;Inappropriate antidiuretic hormone secretion syndrome;Nephrogenic diabetes insipidus. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/V2R_HUMAN V2R_HUMAN] Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.<ref>PMID:19440390</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bous J]]
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[[Category: Couvineau P]]
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[[Category: Fouillen A]]
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[[Category: Gilles N]]
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[[Category: Granier S]]
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[[Category: Mary C]]
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[[Category: Mendre C]]
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[[Category: Mouillac B]]
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[[Category: Orcel H]]
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[[Category: Schulte G]]

Current revision

Cryo-EM structure of inactive human arginine-vasopressin (AVP) V2 receptor (V2R) with tolvaptan

PDB ID 9hap

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OCA

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