9hla

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:29, 4 June 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9hla is ON HOLD until Paper Publication
+
==TRPML1 in complex with compound 9a==
-
 
+
<StructureSection load='9hla' size='340' side='right'caption='[[9hla]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9hla]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HLA FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8K6:OCTADECANE'>8K6</scene>, <scene name='pdbligand=A1IV3:~{N}-[(1~{R},2~{R})-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide'>A1IV3</scene>, <scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=EUJ:[(2~{R})-2-octanoyloxy-3-[oxidanyl-[(2~{R},3~{R},5~{S},6~{R})-2,4,6-tris(oxidanyl)-3,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl]+octanoate'>EUJ</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hla OCA], [https://pdbe.org/9hla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hla RCSB], [https://www.ebi.ac.uk/pdbsum/9hla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hla ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN] Mucolipidosis type 4. The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN] Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.<ref>PMID:12459486</ref> <ref>PMID:14749347</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Clark M]]
 +
[[Category: Cowan SR]]
 +
[[Category: Di Daniel E]]
 +
[[Category: Earl CP]]
 +
[[Category: Fisher S]]
 +
[[Category: Holvey RS]]
 +
[[Category: Jackson SM]]
 +
[[Category: Johnson CN]]
 +
[[Category: Lloyd-Evans E]]
 +
[[Category: Mahajan P]]
 +
[[Category: Morgillo CM]]
 +
[[Category: Mortenson PN]]
 +
[[Category: O'Reilly M]]
 +
[[Category: Reeks J]]
 +
[[Category: Richardson CJ]]
 +
[[Category: Schopf P]]
 +
[[Category: Tams DM]]
 +
[[Category: Waller-Evans H]]
 +
[[Category: Ward SE]]
 +
[[Category: Whibley S]]
 +
[[Category: Williams PA]]

Current revision

TRPML1 in complex with compound 9a

PDB ID 9hla

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9hla"
Personal tools