9ogk

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m (Protected "9ogk" [edit=sysop:move=sysop])
Current revision (08:39, 4 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9ogk is ON HOLD
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==Refinement of PDB-3J5R against EMD-8117 using EMAN2==
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<StructureSection load='9ogk' size='340' side='right'caption='[[9ogk]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
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Authors: Chen, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ogk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OGK FirstGlance]. <br>
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Description: Refinement of PDB-3J5R against EMD-8117 using EMAN2.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ogk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ogk OCA], [https://pdbe.org/9ogk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ogk RCSB], [https://www.ebi.ac.uk/pdbsum/9ogk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ogk ProSAT]</span></td></tr>
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[[Category: Chen, M]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRPV1_RAT TRPV1_RAT] Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.<ref>PMID:9349813</ref> <ref>PMID:10644739</ref> <ref>PMID:11140687</ref> <ref>PMID:11418861</ref> <ref>PMID:12095983</ref> <ref>PMID:12194871</ref> <ref>PMID:12808128</ref> <ref>PMID:14523239</ref> <ref>PMID:12764195</ref> <ref>PMID:14630912</ref> <ref>PMID:15173182</ref> <ref>PMID:21076423</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Chen M]]

Current revision

Refinement of PDB-3J5R against EMD-8117 using EMAN2

PDB ID 9ogk

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