9oma
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of PCMTD1-ELOBC-CUL5-RBX2 (CRL5-PCMTD1)== | |
| - | + | <StructureSection load='9oma' size='340' side='right'caption='[[9oma]], [[Resolution|resolution]] 4.14Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9oma]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OMA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.14Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9oma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9oma OCA], [https://pdbe.org/9oma PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9oma RCSB], [https://www.ebi.ac.uk/pdbsum/9oma PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9oma ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PCMD1_HUMAN PCMD1_HUMAN] Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35486881). Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity (PubMed:35486881). May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein (PubMed:35486881).<ref>PMID:35486881</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Clarke SG]] | ||
| + | [[Category: Flowers C]] | ||
| + | [[Category: Loo JA]] | ||
| + | [[Category: Oroudjeva E]] | ||
| + | [[Category: Pandey V]] | ||
| + | [[Category: Pang EZ]] | ||
| + | [[Category: Rodriguez JA]] | ||
| + | [[Category: Sawaya MR]] | ||
| + | [[Category: Winters JB]] | ||
| + | [[Category: Wohlschlegel W]] | ||
| + | [[Category: Zhao B]] | ||
Current revision
Cryo-EM structure of PCMTD1-ELOBC-CUL5-RBX2 (CRL5-PCMTD1)
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Categories: Homo sapiens | Large Structures | Clarke SG | Flowers C | Loo JA | Oroudjeva E | Pandey V | Pang EZ | Rodriguez JA | Sawaya MR | Winters JB | Wohlschlegel W | Zhao B
