7k1w
From Proteopedia
(Difference between revisions)
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<StructureSection load='7k1w' size='340' side='right'caption='[[7k1w]], [[Resolution|resolution]] 5.10Å' scene=''> | <StructureSection load='7k1w' size='340' side='right'caption='[[7k1w]], [[Resolution|resolution]] 5.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K1W FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.1Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.1Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1w OCA], [https://pdbe.org/7k1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1w RCSB], [https://www.ebi.ac.uk/pdbsum/7k1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1w ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1w OCA], [https://pdbe.org/7k1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1w RCSB], [https://www.ebi.ac.uk/pdbsum/7k1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/FIG4_HUMAN FIG4_HUMAN] Amyotrophic lateral sclerosis;Bilateral parasagittal parieto-occipital polymicrogyria;Charcot-Marie-Tooth disease type 4J;Yunis-Varon syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/FIG4_HUMAN FIG4_HUMAN] Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:17556371, PubMed:33098764). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate (PubMed:33098764). Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production (PubMed:33098764). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro (PubMed:17556371).<ref>PMID:17556371</ref> <ref>PMID:33098764</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lees JA]] | [[Category: Lees JA]] | ||
[[Category: Li P]] | [[Category: Li P]] | ||
[[Category: Reinisch KM]] | [[Category: Reinisch KM]] | ||
Current revision
PIKfyve/Fig4/Vac14 complex centered on Fig4 - map3
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