9l4c

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m (Protected "9l4c" [edit=sysop:move=sysop])
Current revision (09:22, 4 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9l4c is ON HOLD
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==ATR Spiral -ATRIP bound with RP-3500==
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<StructureSection load='9l4c' size='340' side='right'caption='[[9l4c]], [[Resolution|resolution]] 4.06&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9l4c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L4C FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.06&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l4c OCA], [https://pdbe.org/9l4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l4c RCSB], [https://www.ebi.ac.uk/pdbsum/9l4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l4c ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ATR_HUMAN ATR_HUMAN] Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome;Seckel syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/ATR_HUMAN ATR_HUMAN] Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.<ref>PMID:10597277</ref> <ref>PMID:10608806</ref> <ref>PMID:10859164</ref> <ref>PMID:11114888</ref> <ref>PMID:11418864</ref> <ref>PMID:11673449</ref> <ref>PMID:11721054</ref> <ref>PMID:11865061</ref> <ref>PMID:12526805</ref> <ref>PMID:12791985</ref> <ref>PMID:12814551</ref> <ref>PMID:14657349</ref> <ref>PMID:14729973</ref> <ref>PMID:14742437</ref> <ref>PMID:15210935</ref> <ref>PMID:15314022</ref> <ref>PMID:15496423</ref> <ref>PMID:16260606</ref> <ref>PMID:21144835</ref> <ref>PMID:27723717</ref> <ref>PMID:27723720</ref> <ref>PMID:9427750</ref> <ref>PMID:9636169</ref> <ref>PMID:9925639</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Wang G]]

Current revision

ATR Spiral -ATRIP bound with RP-3500

PDB ID 9l4c

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