User:Eduarda Franco Marcolino/Sandbox 1
From Proteopedia
(Difference between revisions)
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- | ==Your Heading Here (maybe something like 'Structure')== BOVINE METHIONINE SULFOXIDE REDUCTASE | + | ==Your Heading Here (maybe something like 'Structure')== ==BOVINE METHIONINE SULFOXIDE REDUCTASE== |
<StructureSection load='1FVA' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1FVA' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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== Function == | == Function == | ||
- | Reactive oxygen species (ROS) and nitrogen intermediates can cause cellular damage. Cells have developed several mechanisms to eliminate these reactive molecules or repair the damage. Among proteins, one of the amino acids most easily oxidized is methionine, which is converted into methionine sulfoxide. The enzyme peptide methionine sulfoxide reductase (MsrA) catalyzes the reduction of methionine sulfoxide back to methionine, both in proteins and as free methionine. MsrA plays an important role in protecting the cell against oxidative damage. | + | Reactive oxygen species (ROS) and nitrogen intermediates can cause cellular damage. Cells have developed several mechanisms to eliminate these reactive molecules or repair the damage. Among proteins, one of the amino acids most easily oxidized is methionine, which is converted into methionine sulfoxide. The enzyme '''peptide methionine sulfoxide reductase (MsrA)''' catalyzes the reduction of methionine sulfoxide back to methionine, both in proteins and as free methionine. MsrA plays an important role in protecting the cell against oxidative damage. |
== Disease == | == Disease == |
Revision as of 11:00, 7 June 2025
Your Heading Here (maybe something like 'Structure')== ==BOVINE METHIONINE SULFOXIDE REDUCTASE
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References
Lowther, W. T, et al. “Structure and Mechanism of Peptide Methionine Sulfoxide Reductase, an “Anti-Oxidation” Enzyme,.” Biochemistry, vol. 39, no. 44, 13 Oct. 2000, pp. 13307–13312, https://doi.org/10.1021/bi0020269. Accessed 1 Aug. 2022.
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644