1w1f

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[[Image:1w1f.gif|left|200px]]
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{{Structure
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|PDB= 1w1f |SIZE=350|CAPTION= <scene name='initialview01'>1w1f</scene>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w1f OCA], [http://www.ebi.ac.uk/pdbsum/1w1f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w1f RCSB]</span>
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'''SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE'''
'''SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE'''
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[[Category: Schweimer, K.]]
[[Category: Schweimer, K.]]
[[Category: Sticht, H.]]
[[Category: Sticht, H.]]
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[[Category: lyn]]
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[[Category: Lyn]]
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[[Category: sh3 domain]]
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[[Category: Sh3 domain]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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[[Category: tyrosine kinase]]
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[[Category: Tyrosine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:29:45 2008''
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Revision as of 10:01, 3 May 2008

Image:1w1f.gif

Template:STRUCTURE 1w1f

SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE


Overview

The Src homology 3 (SH3) domain of the Src family kinase Lyn binds to the herpesviral tyrosine kinase interacting protein (Tip) more than one order of magnitude stronger than other closely related members of the Src family. In order to identify the molecular basis for high-affinity binding, the structure of free and Tip-bound Lyn-SH3 was determined by NMR spectroscopy. Tip forms additional contacts outside its classical proline-rich recognition motif and, in particular, a strictly conserved leucine (L186) of the C-terminally adjacent sequence stretch packs into a hydrophobic pocket on the Lyn surface. Although the existence of this pocket is no unique property of Lyn-SH3, Lyn is the only Src family kinase that contains an additional aromatic residue (H41) in the n-Src loop as part of this pocket. H41 covers L186 of Tip by forming tight hydrophobic contacts, and model calculations suggest that the increase in binding affinity compared with other SH3 domains can mainly be attributed to these additional interactions. These findings indicate that this pocket can mediate specificity even between otherwise closely related SH3 domains.

About this Structure

1W1F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity., Bauer F, Schweimer K, Meiselbach H, Hoffmann S, Rosch P, Sticht H, Protein Sci. 2005 Oct;14(10):2487-98. Epub 2005 Sep 9. PMID:16155203 Page seeded by OCA on Sat May 3 13:01:16 2008

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