1w33

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[[Image:1w33.gif|left|200px]]
[[Image:1w33.gif|left|200px]]
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{{Structure
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|PDB= 1w33 |SIZE=350|CAPTION= <scene name='initialview01'>1w33</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1w33", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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{{STRUCTURE_1w33| PDB=1w33 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w33 OCA], [http://www.ebi.ac.uk/pdbsum/1w33 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w33 RCSB]</span>
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'''BBCRASP-1 FROM BORRELIA BURGDORFERI'''
'''BBCRASP-1 FROM BORRELIA BURGDORFERI'''
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[[Category: Wallich, R.]]
[[Category: Wallich, R.]]
[[Category: Zipfel, P.]]
[[Category: Zipfel, P.]]
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[[Category: complement regulator acquiring surface protein]]
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[[Category: Complement regulator acquiring surface protein]]
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[[Category: factor h binding]]
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[[Category: Factor h binding]]
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[[Category: lyme borreliosis]]
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[[Category: Lyme borreliosis]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: tick]]
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[[Category: Tick]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:05:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:30:28 2008''
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Revision as of 10:05, 3 May 2008

Image:1w33.gif


PDB ID 1w33

Drag the structure with the mouse to rotate
1w33, resolution 2.70Å ()
Ligands:
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



BBCRASP-1 FROM BORRELIA BURGDORFERI


Overview

Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design.

About this Structure

1W33 is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564 Page seeded by OCA on Sat May 3 13:05:15 2008

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