9ca8

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Current revision (10:52, 18 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9ca8 is ON HOLD until Paper Publication
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==Cryo-EM structure of human SRCAP-nucleosome complex in the partially-engaged state (composite structure)==
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<StructureSection load='9ca8' size='340' side='right'caption='[[9ca8]], [[Resolution|resolution]] 3.92&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ca8]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CA8 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.92&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ca8 OCA], [https://pdbe.org/9ca8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ca8 RCSB], [https://www.ebi.ac.uk/pdbsum/9ca8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ca8 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SRCAP_HUMAN SRCAP_HUMAN] Floating-Harbor syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SRCAP_HUMAN SRCAP_HUMAN] Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.<ref>PMID:10347196</ref> <ref>PMID:11522779</ref> <ref>PMID:14500758</ref> <ref>PMID:16024792</ref> <ref>PMID:16634648</ref> <ref>PMID:17617668</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Xenopus laevis]]
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[[Category: Louder RK]]
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[[Category: Park G]]
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[[Category: Patel AB]]

Current revision

Cryo-EM structure of human SRCAP-nucleosome complex in the partially-engaged state (composite structure)

PDB ID 9ca8

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OCA

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