9cl0

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Current revision (10:53, 18 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9cl0 is ON HOLD until Paper Publication
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==Cryo-EM structure of human XPR1 in presence of inorganic phosphate and phytic acid==
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<StructureSection load='9cl0' size='340' side='right'caption='[[9cl0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9cl0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CL0 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cl0 OCA], [https://pdbe.org/9cl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cl0 RCSB], [https://www.ebi.ac.uk/pdbsum/9cl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cl0 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/S53A1_HUMAN S53A1_HUMAN] Bilateral striopallidodentate calcinosis. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/S53A1_HUMAN S53A1_HUMAN] Inorganic ion transporter that mediates phosphate ion export across plasma membrane. Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling. The molecular mechanism of phosphate transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (By similarity) (PubMed:23791524, PubMed:25938945, PubMed:31043717). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), important intracellular signaling molecules involved in regulation of phosphate flux (PubMed:27080106).[UniProtKB:Q9Z0U0]<ref>PMID:23791524</ref> <ref>PMID:25938945</ref> <ref>PMID:27080106</ref> <ref>PMID:31043717</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Wang Z]]
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[[Category: Wu H]]

Current revision

Cryo-EM structure of human XPR1 in presence of inorganic phosphate and phytic acid

PDB ID 9cl0

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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