9j1n

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Current revision (11:05, 18 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9j1n is ON HOLD until Paper Publication
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==Mouse Spi-B Ets domain in complex with DNA containing AGAA sequence==
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<StructureSection load='9j1n' size='340' side='right'caption='[[9j1n]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
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Authors: Nonaka, Y., Kamitori, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9j1n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J1N FirstGlance]. <br>
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Description: Mouse Spi-B Ets domain in complex with DNA containing AGAA sequence
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3D1:(2R,3S,5R)-5-(6-AMINO-9H-PURIN-9-YL)-TETRAHYDRO-2-(HYDROXYMETHYL)FURAN-3-OL'>3D1</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
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[[Category: Kamitori, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j1n OCA], [https://pdbe.org/9j1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j1n RCSB], [https://www.ebi.ac.uk/pdbsum/9j1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j1n ProSAT]</span></td></tr>
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[[Category: Nonaka, Y]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPIB_MOUSE SPIB_MOUSE] Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.<ref>PMID:10229183</ref> <ref>PMID:11313289</ref> <ref>PMID:11672537</ref> <ref>PMID:11980719</ref> <ref>PMID:12431391</ref> <ref>PMID:8691135</ref> <ref>PMID:9384589</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Kamitori S]]
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[[Category: Nonaka Y]]

Current revision

Mouse Spi-B Ets domain in complex with DNA containing AGAA sequence

PDB ID 9j1n

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