1w3z

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[[Image:1w3z.gif|left|200px]]
[[Image:1w3z.gif|left|200px]]
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{{Structure
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|PDB= 1w3z |SIZE=350|CAPTION= <scene name='initialview01'>1w3z</scene>, resolution 3.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1w3z", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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{{STRUCTURE_1w3z| PDB=1w3z | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3z OCA], [http://www.ebi.ac.uk/pdbsum/1w3z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w3z RCSB]</span>
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'''SEMET DERIVATIVE OF BBCRASP-1 FROM BORRELIA BURGDORFERI'''
'''SEMET DERIVATIVE OF BBCRASP-1 FROM BORRELIA BURGDORFERI'''
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[[Category: Wallich, R.]]
[[Category: Wallich, R.]]
[[Category: Zipfel, P.]]
[[Category: Zipfel, P.]]
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[[Category: complement regulator acquiring surface protein]]
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[[Category: Complement regulator acquiring surface protein]]
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[[Category: factor h binding]]
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[[Category: Factor h binding]]
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[[Category: lyme borreliosis]]
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[[Category: Lyme borreliosis]]
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[[Category: selenomethionine]]
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[[Category: Selenomethionine]]
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[[Category: tick]]
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[[Category: Tick]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:07:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:30:56 2008''
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Revision as of 10:07, 3 May 2008

Image:1w3z.gif

Template:STRUCTURE 1w3z

SEMET DERIVATIVE OF BBCRASP-1 FROM BORRELIA BURGDORFERI


Overview

Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design.

About this Structure

1W3Z is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564 Page seeded by OCA on Sat May 3 13:07:39 2008

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