9bq8

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Current revision (06:07, 25 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9bq8 is ON HOLD until Paper Publication
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==Human Topoisomerase 2 Beta ATPase domain bound to non-hydrolyzable ATP analog AMPPNP==
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<StructureSection load='9bq8' size='340' side='right'caption='[[9bq8]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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Authors: Cong, A.T.Q., Austin, C.A., Kubes, J., Karabanovich, G., Melnikova, I., Lencova, O., Kollarova, P., Piskackova, H.B., Kerestes, V., Applova, L., Arrouye, L., Alvey, J.A., Paluncic, J., Witter, T.L., Jirkovska, A., Kunes, J., Sterbova, P., Sterba, M., Simunek, T., Roh, J., Schellenberg, M.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9bq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BQ8 FirstGlance]. <br>
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Description: Human Topoisomerase 2 Beta ATPase domain bound to non-hydrolyzable ATP analog AMPPNP
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Schellenberg, M.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bq8 OCA], [https://pdbe.org/9bq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bq8 RCSB], [https://www.ebi.ac.uk/pdbsum/9bq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bq8 ProSAT]</span></td></tr>
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[[Category: Jirkovska, A]]
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</table>
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[[Category: Applova, L]]
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== Function ==
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[[Category: Kunes, J]]
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[https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>
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[[Category: Melnikova, I]]
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== References ==
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[[Category: Kerestes, V]]
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<references/>
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[[Category: Alvey, J.A]]
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__TOC__
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[[Category: Karabanovich, G]]
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</StructureSection>
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[[Category: Lencova, O]]
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[[Category: Homo sapiens]]
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[[Category: Roh, J]]
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[[Category: Large Structures]]
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[[Category: Paluncic, J]]
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[[Category: Alvey JA]]
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[[Category: Sterbova, P]]
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[[Category: Applova L]]
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[[Category: Simunek, T]]
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[[Category: Arrouye L]]
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[[Category: Austin, C.A]]
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[[Category: Austin CA]]
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[[Category: Arrouye, L]]
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[[Category: Cong ATQ]]
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[[Category: Cong, A.T.Q]]
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[[Category: Jirkovska A]]
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[[Category: Kubes, J]]
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[[Category: Karabanovich G]]
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[[Category: Kollarova, P]]
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[[Category: Kerestes V]]
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[[Category: Sterba, M]]
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[[Category: Kollarova P]]
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[[Category: Witter, T.L]]
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[[Category: Kubes J]]
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[[Category: Piskackova, H.B]]
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[[Category: Kunes J]]
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[[Category: Lencova O]]
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[[Category: Melnikova I]]
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[[Category: Paluncic J]]
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[[Category: Piskackova HB]]
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[[Category: Roh J]]
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[[Category: Schellenberg MJ]]
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[[Category: Simunek T]]
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[[Category: Sterba M]]
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[[Category: Sterbova P]]
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[[Category: Witter TL]]

Current revision

Human Topoisomerase 2 Beta ATPase domain bound to non-hydrolyzable ATP analog AMPPNP

PDB ID 9bq8

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