1w4r

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[[Image:1w4r.gif|left|200px]]
[[Image:1w4r.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1w4r |SIZE=350|CAPTION= <scene name='initialview01'>1w4r</scene>, resolution 1.83&Aring;
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The line below this paragraph, containing "STRUCTURE_1w4r", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Dtu+Binding+Site+For+Chain+E'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DTU:(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTU</scene>, <scene name='pdbligand=TTP:THYMIDINE-5&#39;-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1w4r| PDB=1w4r | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4r OCA], [http://www.ebi.ac.uk/pdbsum/1w4r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w4r RCSB]</span>
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}}
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'''STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP'''
'''STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP'''
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[[Category: Scapozza, L.]]
[[Category: Scapozza, L.]]
[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
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[[Category: cytosolic]]
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[[Category: Cytosolic]]
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[[Category: human]]
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[[Category: Human]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: thymidine kinase]]
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[[Category: Thymidine kinase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: type ii]]
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[[Category: Type ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:09:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:31:09 2008''
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Revision as of 10:09, 3 May 2008

Image:1w4r.gif

Template:STRUCTURE 1w4r

STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP


Overview

The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This structure is the first representative of the type II thymidine kinases found in several pathogens. The structure deviates strongly from the known structures of type I thymidine kinases such as the Herpes simplex enzyme. It contains a zinc-binding domain with four cysteines complexing a structural zinc ion. Interestingly, the backbone atoms of the type II enzyme bind thymine via hydrogen-bonds, in contrast to type I, where side chains are involved. This results in a specificity difference exploited for antiviral therapy. The presented structure will foster the development of new drugs and prodrugs for numerous therapeutic applications.

About this Structure

1W4R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a type II thymidine kinase with bound dTTP., Birringer MS, Claus MT, Folkers G, Kloer DP, Schulz GE, Scapozza L, FEBS Lett. 2005 Feb 28;579(6):1376-82. PMID:15733844 Page seeded by OCA on Sat May 3 13:09:17 2008

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