9h6n
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Flavin-dependent tryptophan 6-halogenase Thal in complex with 6-bromo-L-tryptophan== | |
| - | + | <StructureSection load='9h6n' size='340' side='right'caption='[[9h6n]], [[Resolution|resolution]] 2.33Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9h6n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_albogriseolus Streptomyces albogriseolus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9H6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9H6N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9h6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9h6n OCA], [https://pdbe.org/9h6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9h6n RCSB], [https://www.ebi.ac.uk/pdbsum/9h6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9h6n ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRP6H_STRAO TRP6H_STRAO] Involved in the biosynthesis of thienodolin, a plant growth-regulating compound (PubMed:24692213). Catalyzes the chlorination of tryptophan (Trp) at C6 position to yield 6-chloro-tryptophan (PubMed:24692213, PubMed:33465708). It is also able to use bromide ions to generate monobrominated Trp (PubMed:33465708, PubMed:36259362). In vitro, accepts a wide range of amides and peptides carrying either L- or D-Trp at the N-terminus (PubMed:36259362).<ref>PMID:24692213</ref> <ref>PMID:33465708</ref> <ref>PMID:36259362</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces albogriseolus]] | ||
| + | [[Category: Bork S]] | ||
| + | [[Category: Niemann HH]] | ||
Current revision
Flavin-dependent tryptophan 6-halogenase Thal in complex with 6-bromo-L-tryptophan
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