9nbs

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'''Unreleased structure'''
 
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The entry 9nbs is ON HOLD until Paper Publication
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==Structure of HPK1 with compound R2==
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<StructureSection load='9nbs' size='340' side='right'caption='[[9nbs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Kiefer, J.R., Walters, B.T., Wang, W., Wu, P., Duo, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9nbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NBS FirstGlance]. <br>
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Description: Structure of HPK1 with compound R2
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BW4:(1~{S},3~{R})-4-chloranyl-1-methyl-5-[3-(1-methyl-2-oxidanylidene-pyridin-3-yl)phenyl]spiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,3-cyclopentane]-1-carboxamide'>A1BW4</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Kiefer, J.R]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nbs OCA], [https://pdbe.org/9nbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nbs RCSB], [https://www.ebi.ac.uk/pdbsum/9nbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nbs ProSAT]</span></td></tr>
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[[Category: Wu, P]]
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</table>
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[[Category: Wang, W]]
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== Function ==
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[[Category: Walters, B.T]]
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[https://www.uniprot.org/uniprot/M4K1_HUMAN M4K1_HUMAN] Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.<ref>PMID:24362026</ref> <ref>PMID:8824585</ref>
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[[Category: Duo, Y]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Duo Y]]
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[[Category: Kiefer JR]]
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[[Category: Walters BT]]
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[[Category: Wang W]]
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[[Category: Wu P]]

Revision as of 06:22, 25 June 2025

Structure of HPK1 with compound R2

PDB ID 9nbs

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