9nc2

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'''Unreleased structure'''
 
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The entry 9nc2 is ON HOLD until Paper Publication
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==Structure of HPK1 with compound C3==
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<StructureSection load='9nc2' size='340' side='right'caption='[[9nc2]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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Authors: Kiefer, J.R., Walters, B.T., Wang, W., Wu, P., Duo, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9nc2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NC2 FirstGlance]. <br>
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Description: Structure of HPK1 with compound C3
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F97:N-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3R)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-amine'>F97</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Wu, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nc2 OCA], [https://pdbe.org/9nc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nc2 RCSB], [https://www.ebi.ac.uk/pdbsum/9nc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nc2 ProSAT]</span></td></tr>
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[[Category: Walters, B.T]]
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</table>
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[[Category: Wang, W]]
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== Function ==
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[[Category: Duo, Y]]
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[https://www.uniprot.org/uniprot/M4K1_HUMAN M4K1_HUMAN] Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.<ref>PMID:24362026</ref> <ref>PMID:8824585</ref>
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[[Category: Kiefer, J.R]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Duo Y]]
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[[Category: Kiefer JR]]
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[[Category: Walters BT]]
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[[Category: Wang W]]
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[[Category: Wu P]]

Revision as of 06:23, 25 June 2025

Structure of HPK1 with compound C3

PDB ID 9nc2

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