9o58

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Current revision (06:24, 25 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9o58 is ON HOLD until Paper Publication
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==Zymogen ADAM17-iRhom2 complex bound by the MEDI3622 Fab==
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<StructureSection load='9o58' size='340' side='right'caption='[[9o58]], [[Resolution|resolution]] 3.53&Aring;' scene=''>
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Authors: Slone, C.E., Maciag, J.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9o58]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O58 FirstGlance]. <br>
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Description: Zymogen ADAM17-iRhom2 complex bound by the MEDI3622 Fab
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.53&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Slone, C.E]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o58 OCA], [https://pdbe.org/9o58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o58 RCSB], [https://www.ebi.ac.uk/pdbsum/9o58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o58 ProSAT]</span></td></tr>
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[[Category: Maciag, J.J]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN] Defects in ADAM17 are a cause of neonatal inflammatory skin and bowel disease (NISBD) [MIM:[https://omim.org/entry/614328 614328]. NISBD is a disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.<ref>PMID:22010916</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN] Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).<ref>PMID:12441351</ref> <ref>PMID:20592283</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aequorea victoria]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Maciag JJ]]
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[[Category: Slone CE]]

Current revision

Zymogen ADAM17-iRhom2 complex bound by the MEDI3622 Fab

PDB ID 9o58

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