7w6s

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:38, 25 June 2025) (edit) (undo)
 
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7w6s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W6S FirstGlance]. <br>
<table><tr><td colspan='2'>[[7w6s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W6S FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w6s OCA], [https://pdbe.org/7w6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w6s RCSB], [https://www.ebi.ac.uk/pdbsum/7w6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w6s ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w6s OCA], [https://pdbe.org/7w6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w6s RCSB], [https://www.ebi.ac.uk/pdbsum/7w6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w6s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[https://www.uniprot.org/uniprot/KCIP2_HUMAN KCIP2_HUMAN] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).[UniProtKB:Q9JJ69]<ref>PMID:10676964</ref> <ref>PMID:11287421</ref> <ref>PMID:11684073</ref> <ref>PMID:12297301</ref> <ref>PMID:12829703</ref> <ref>PMID:14623880</ref>
+
[https://www.uniprot.org/uniprot/KCIP2_HUMAN KCIP2_HUMAN] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220). Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220). Involved in KCND2 and KCND3 trafficking to the cell surface (PubMed:12829703). May be required for the expression of I(To) currents in the heart (By similarity).[UniProtKB:Q9JJ69]<ref>PMID:10676964</ref> <ref>PMID:11287421</ref> <ref>PMID:11684073</ref> <ref>PMID:12297301</ref> <ref>PMID:12829703</ref> <ref>PMID:14623880</ref> <ref>PMID:34997220</ref>
 +
 
 +
==See Also==
 +
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>

Current revision

CryoEM structure of human KChIP2-Kv4.3 complex

PDB ID 7w6s

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7w6s"
Personal tools