1w5f

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[[Image:1w5f.jpg|left|200px]]
[[Image:1w5f.jpg|left|200px]]
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{{Structure
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|PDB= 1w5f |SIZE=350|CAPTION= <scene name='initialview01'>1w5f</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1w5f", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:G2p+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1w5f| PDB=1w5f | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5f OCA], [http://www.ebi.ac.uk/pdbsum/1w5f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w5f RCSB]</span>
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}}
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'''FTSZ, T7 MUTATED, DOMAIN SWAPPED (T. MARITIMA)'''
'''FTSZ, T7 MUTATED, DOMAIN SWAPPED (T. MARITIMA)'''
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[[Category: Lowe, J.]]
[[Category: Lowe, J.]]
[[Category: Oliva, M A.]]
[[Category: Oliva, M A.]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: cell-division protein]]
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[[Category: Cell-division protein]]
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[[Category: complete proteome]]
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[[Category: Complete proteome]]
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[[Category: domain swapped]]
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[[Category: Domain swapped]]
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[[Category: filament]]
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[[Category: Filament]]
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[[Category: ftsz]]
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[[Category: Ftsz]]
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[[Category: gtp-binding]]
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[[Category: Gtp-binding]]
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[[Category: gtpase]]
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[[Category: Gtpase]]
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[[Category: multigene family]]
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[[Category: Multigene family]]
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[[Category: septation]]
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[[Category: Septation]]
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[[Category: tubulin]]
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[[Category: Tubulin]]
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[[Category: z-ring]]
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[[Category: Z-ring]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:11:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:31:27 2008''
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Revision as of 10:11, 3 May 2008

Image:1w5f.jpg

Template:STRUCTURE 1w5f

FTSZ, T7 MUTATED, DOMAIN SWAPPED (T. MARITIMA)


Overview

The prokaryotic tubulin homolog FtsZ polymerizes into a ring structure essential for bacterial cell division. We have used refolded FtsZ to crystallize a tubulin-like protofilament. The N- and C-terminal domains of two consecutive subunits in the filament assemble to form the GTPase site, with the C-terminal domain providing water-polarizing residues. A domain-swapped structure of FtsZ and biochemical data on purified N- and C-terminal domains show that they are independent. This leads to a model of how FtsZ and tubulin polymerization evolved by fusing two domains. In polymerized tubulin, the nucleotide-binding pocket is occluded, which leads to nucleotide exchange being the rate-limiting step and to dynamic instability. In our FtsZ filament structure the nucleotide is exchangeable, explaining why, in this filament, nucleotide hydrolysis is the rate-limiting step during FtsZ polymerization. Furthermore, crystal structures of FtsZ in different nucleotide states reveal notably few differences.

About this Structure

1W5F is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structural insights into FtsZ protofilament formation., Oliva MA, Cordell SC, Lowe J, Nat Struct Mol Biol. 2004 Dec;11(12):1243-50. Epub 2004 Nov 21. PMID:15558053 Page seeded by OCA on Sat May 3 13:11:11 2008

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OCA

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