8yvk
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Neuraminidase of A/Red knot/Delaware Bay/310/2016 H10N4 in complex with CAV-F6 Fab== | |
| - | + | <StructureSection load='8yvk' size='340' side='right'caption='[[8yvk]], [[Resolution|resolution]] 3.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8yvk]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/red_knot/Delaware_Bay/310/2016(H10N4)) Influenza A virus (A/red knot/Delaware Bay/310/2016(H10N4))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YVK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.09Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yvk OCA], [https://pdbe.org/8yvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yvk RCSB], [https://www.ebi.ac.uk/pdbsum/8yvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yvk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A248T7C3_9INFA A0A248T7C3_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ge J]] | ||
| + | [[Category: Li X]] | ||
| + | [[Category: Wang X]] | ||
Current revision
Neuraminidase of A/Red knot/Delaware Bay/310/2016 H10N4 in complex with CAV-F6 Fab
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Categories: Homo sapiens | Large Structures | Ge J | Li X | Wang X
