9frg

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Current revision (05:26, 3 July 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9frg is ON HOLD until Paper Publication
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==CryoEM structure of human rho1 GABAA receptor in complex with (S)-GABOB in the desensitized state==
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<StructureSection load='9frg' size='340' side='right'caption='[[9frg]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9frg]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FRG FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IFH:(3~{S})-4-azanyl-3-oxidanyl-butanoic+acid'>A1IFH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9frg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9frg OCA], [https://pdbe.org/9frg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9frg RCSB], [https://www.ebi.ac.uk/pdbsum/9frg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9frg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GBRR1_HUMAN GBRR1_HUMAN] Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (PubMed:37659407). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:37659407). Rho-1 subunits are primarily expressed in retina where rho-1-containing GABAARs may play a role in retinal neurotransmission (PubMed:1849271). Rho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity).[UniProtKB:P56475]<ref>PMID:1849271</ref> <ref>PMID:37659407</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fan C]]
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[[Category: Howard RJ]]
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[[Category: Lindahl E]]

Current revision

CryoEM structure of human rho1 GABAA receptor in complex with (S)-GABOB in the desensitized state

PDB ID 9frg

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