9il4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure and iron-transporting mechanism of BOCT1== | |
| - | + | <StructureSection load='9il4' size='340' side='right'caption='[[9il4]], [[Resolution|resolution]] 3.33Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9il4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_spicilegus Mus spicilegus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IL4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.33Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9il4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9il4 OCA], [https://pdbe.org/9il4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9il4 RCSB], [https://www.ebi.ac.uk/pdbsum/9il4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9il4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A8C6HDX9_MUSSI A0A8C6HDX9_MUSSI] Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.[ARBA:ARBA00054975] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus spicilegus]] | ||
| + | [[Category: Chen J]] | ||
| + | [[Category: Chen L]] | ||
Current revision
Structure and iron-transporting mechanism of BOCT1
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