9mu0
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==I4A variant of mini-alphaA crystallin== | |
| - | + | <StructureSection load='9mu0' size='340' side='right'caption='[[9mu0]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9mu0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MU0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 7 models</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mu0 OCA], [https://pdbe.org/9mu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mu0 RCSB], [https://www.ebi.ac.uk/pdbsum/9mu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mu0 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/CRYAA_HUMAN CRYAA_HUMAN] Early-onset lamellar cataract;Early-onset nuclear cataract;Total early-onset cataract;Cataract-microcornea syndrome;Early-onset anterior polar cataract. Alpha-crystallin A 1-172 is found at nearly twofold higher levels in diabetic lenses than in age-matched control lenses.<ref>PMID:12356833</ref> The disease is caused by mutations affecting the gene represented in this entry. |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CRYAA_HUMAN CRYAA_HUMAN] Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.<ref>PMID:22120592</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Martin RW]] | ||
| + | [[Category: Padilla MSTL]] | ||
| + | [[Category: Sroge CD]] | ||
| + | [[Category: Zhu J]] | ||
Current revision
I4A variant of mini-alphaA crystallin
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