9nr9

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Current revision (05:36, 3 July 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9nr9 is ON HOLD until Paper Publication
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==The structure of GluA1/A4 LBD-TMD with 2 TARPs==
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<StructureSection load='9nr9' size='340' side='right'caption='[[9nr9]], [[Resolution|resolution]] 4.22&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9nr9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NR9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.22&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZK1:{[7-MORPHOLIN-4-YL-2,3-DIOXO-6-(TRIFLUOROMETHYL)-3,4-DIHYDROQUINOXALIN-1(2H)-YL]METHYL}PHOSPHONIC+ACID'>ZK1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nr9 OCA], [https://pdbe.org/9nr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nr9 RCSB], [https://www.ebi.ac.uk/pdbsum/9nr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nr9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCG2_RAT CCG2_RAT] Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.<ref>PMID:17880894</ref> <ref>PMID:18817736</ref> <ref>PMID:19234459</ref> <ref>PMID:19265014</ref> <ref>PMID:20805473</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Fang CF]]
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[[Category: Gouaux E]]

Current revision

The structure of GluA1/A4 LBD-TMD with 2 TARPs

PDB ID 9nr9

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OCA

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