9r87

Structural highlights

Function

MVP_HUMAN Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.^{[1] [2] [3]}

References

1. ↑ Kolli S, Zito CI, Mossink MH, Wiemer EA, Bennett AM. The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J Biol Chem. 2004 Jul 9;279(28):29374-85. Epub 2004 May 7. PMID:15133037 doi:http://dx.doi.org/10.1074/jbc.M313955200
2. ↑ Kim E, Lee S, Mian MF, Yun SU, Song M, Yi KS, Ryu SH, Suh PG. Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. FEBS J. 2006 Feb;273(4):793-804. PMID:16441665 doi:http://dx.doi.org/10.1111/j.1742-4658.2006.05112.x
3. ↑ Steiner E, Holzmann K, Pirker C, Elbling L, Micksche M, Sutterluty H, Berger W. The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals. J Cell Sci. 2006 Feb 1;119(Pt 3):459-69. Epub 2006 Jan 17. PMID:16418217 doi:http://dx.doi.org/10.1242/jcs.02773