7x2u

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Current revision (06:26, 3 July 2025) (edit) (undo)
 
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==Structure of a human NHE3-CHP1 complex in the autoinhibited state==
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<StructureSection load='7x2u' size='340' side='right'caption='[[7x2u]]' scene=''>
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<StructureSection load='7x2u' size='340' side='right'caption='[[7x2u]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7x2u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X2U FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x2u OCA], [https://pdbe.org/7x2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x2u RCSB], [https://www.ebi.ac.uk/pdbsum/7x2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x2u ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=85R:[(2~{R})-2-hexadecanoyloxy-3-[oxidanyl-[(2~{S},3~{S},5~{R},6~{S})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl]+hexadecanoate'>85R</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x2u OCA], [https://pdbe.org/7x2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x2u RCSB], [https://www.ebi.ac.uk/pdbsum/7x2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x2u ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SL9A3_HUMAN SL9A3_HUMAN] Congenital sodium diarrhea;Cystic fibrosis. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SL9A3_HUMAN SL9A3_HUMAN] Plasma membrane Na(+)/H(+) antiporter (PubMed:18829453, PubMed:26358773, PubMed:35613257). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773).[UniProtKB:G3X939]<ref>PMID:18829453</ref> <ref>PMID:24622516</ref> <ref>PMID:26358773</ref> <ref>PMID:35613257</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Dong Y]]
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[[Category: Gao Y]]
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[[Category: Li H]]
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[[Category: Zhang XC]]
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[[Category: Zhao Y]]

Current revision

Structure of a human NHE3-CHP1 complex in the autoinhibited state

PDB ID 7x2u

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OCA

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